2-Acetamido-5-aminopyridine → N-[6-(Acetylamino)pyridin-3-yl]-5-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxamide
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=1)[C:6]([C:19]([OH:21])=O)=[CH:5]2.[C:22]([NH:25][C:26]1[N:31]=[CH:30][C:29]([NH2:32])=[CH:28][CH:27]=1)(=[O:24])[CH3:23]>>[C:22]([NH:25][C:26]1[N:31]=[CH:30][C:29]([NH:32][C:19]([C:6]2[N:7]([CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=3)[C:8]3[C:4]([CH:5]=2)=[CH:3][C:2]([F:1])=[CH:10][CH:9]=3)=[O:21])=[CH:28][CH:27]=1)(=[O:24])[CH3:23]Participants
3
Procedure
Compound No. 11 is prepared from 5-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxylic acid (WO 2006/072736) and 6-acetylamino-3-aminopyridine according to a process similar to that described in example No. 3.
Sources & evidence
- ORD record
- ord-c934fffeeef4461ba2ec14d3f062c82f
- Source dataset
- uspto-grants-2012_07
- Patent number
- US08227489B2
Reaction notes
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