Cyanogen Bromide → HCID 25267750, compound

Participants

Reaction Conditions

Reaction Steps

To a stirring solution of S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl sulfoximide (50 mg, 0.000108 mol) and DMAP (14.5 mg, 0.000216 mol) in DCM (1 mL) was added cyanogen bromide (23 mg, 0.000216 mol) at 25° C. Reaction mixture was stirred at 25-30° C. for 18 hr and then diluted with DCM (10 mL). Organic layer was washed with dil.HCl. Drying over sodium sulfate and evaporation afforded 20 mg of titled compound in 37% yield.

Provenance & Evidence