Sulfuric Acid → HCID 25268093, compound

HRID 1516399Notes

Reaction equation

HRID 1516399 reaction equation
S(=O)(=O)(O)[OH:2].[Cl:6][C:7]1[CH:8]=[CH:9][C:10]([NH:13][C:14]([C:16]2[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:17]=2[NH:23][C:24]([C:26]2[CH:31]=[CH:30][C:29]([S:32]([CH3:37])(=[N:34][C:35]#[N:36])=[O:33])=[CH:28][CH:27]=2)=[O:25])=[O:15])=[N:11][CH:12]=1>O>[Cl:6][C:7]1[CH:8]=[CH:9][C:10]([NH:13][C:14]([C:16]2[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:17]=2[NH:23][C:24]([C:26]2[CH:31]=[CH:30][C:29]([S:32]([CH3:37])(=[N:34][C:35](=[O:2])[NH2:36])=[O:33])=[CH:28][CH:27]=2)=[O:25])=[O:15])=[N:11][CH:12]=1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 25267750HCID 25267750, compound

Product 1

HCID 25268093HCID 25268093, compoundYield 45%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
27.5 °C

Procedure

Sulfuric acid (0.5 mL) was cooled to 5-10° C. To this was added product of Example 15 (150 mg, 0.38 mmol) and reaction mixture was stirred at 25-30° C. for 3 hr. Above reaction mixture was slowly poured in chilled water. Precipitated product was filtered and washed with water. Drying afforded 70 mg of titled compound in 45% yield.

Workup

  1. additionTo this was added
  2. customAbove reaction mixture
  3. filtrationPrecipitated product was filtered
  4. washwashed with water
  5. customDrying

Sources & evidence

ORD record
ord-ca43227ac38b4c348530f6e8138dfd22
Source dataset
uspto-grants-2012_07
Patent number
US08227492B2

Reaction notes

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