Sulfuric Acid → HCID 25267402, compound

Participants

Reaction Conditions

Reaction Steps

To a stirring solution of S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(1-tert-butoxycarbonyl-pyrrolidin-2-carbonyl)sulfoximide (1.2 g, 0.00182 mol, nonpolar isomer) in methanol (4 mL) was added conc. sulfuric acid (0.7 g, 0.00728 mol) at 5-10° C. The reaction mixture was stirred at 25-30° C. for 4 hr and then diluted with water. Product obtained was extracted in chloroform at 8-9 pH. Organic layer was dried and concentrated to give 640 mg of titled product in 63% yield.

Provenance & Evidence