Methanol → Methyl 4-[(2-methoxyethyl)sulfanyl]benzoate

HRID 1516412Notes

Reaction equation

HRID 1516412 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][S:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([OH:12])=[O:11])=[CH:8][CH:7]=1.S(=O)(=O)(O)O.[CH3:20]O>>[CH3:20][O:11][C:10](=[O:12])[C:9]1[CH:13]=[CH:14][C:6]([S:5][CH2:4][CH2:3][O:2][CH3:1])=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 20119783HCID 20119783, compound

Product 1

HCID 58022768Methyl 4-[(2-methoxyethyl)sulfanyl]benzoateYield 78%

Procedure

4-(2-Methoxy-ethylsulfanyl)-benzoic acid was esterified in methanol by adding catalytic amount of sulfuric acid. Subsequent work up afforded 4 g of desired product in 78% yield.

Sources & evidence

ORD record
ord-9fd5dde44a244d938276201ec2b6fe92
Source dataset
uspto-grants-2012_07
Patent number
US08227492B2

Reaction notes

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