Boron tribromide → HCID 25271234, compound

Participants

Reaction Conditions

Reaction Steps

To a stirring solution of S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-methoxyethyl)-N-benzyloxycarbonyl sulfoximide (0.3 g, 0.00046 mol) in DCM (3 mL) was added 1M solution of BBr3 in DCM(0.33 g, 0.00138 mol) at −70° C. under nitrogen atmosphere. Reaction mixture was stirred for 3 hr at 25-30° C. Subsequent work up and column purification (2% methanol in chloroform and 100-200 mesh silica gel) gave 65 mg of desired product in 28% yield.

Provenance & Evidence