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1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → Ppl-100
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 反応物 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 反応物 | (S)-2-methoxycarbonylamino-3,3-diphenyl-propionic acid | HCID 10017620 | — |
| 反応物 | (1S)-4-amino-N-(5-amino-1-hydroxymethyl-pentyl)-N-isobutyl-benzenesulfonamide | HCID 20595420 | — |
| 生成物 | Ppl-100 | HCID 513956 | — |
反応手順
The title compound was prepared from (1S)-4-amino-N-(5-amino-1-hydroxymethyl-pentyl)-N-isobutyl-benzenesulfonamide (VII-deprotected) (step D) and (2S)-2-methoxycarbonylamino-3,3-diphenyl-propionic acid (step E) using the coupling procedure with HOBt and EDAC described in example 3 (step D). The final product was obtained in 67% yield (121 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08227450B2 |
| 出典データセット | uspto-grants-2012_07 |
| ORD ID | ord-a1f2d06e1a5744d58975602313b4d9eb |
| 出典メモ | uspto-grants-2012_07 |