Citric Acid → HCID 67426433, compound

Participants

Reaction Steps

To a mixture of 4-[4-(4-iodobenzotriazol-1-yl)-pyrimidin-2-ylamino]-cyclohexane-carboxylic acid ethyl ester (2.56 g) in THF (20 mL), EtOH (20 mL) and H2O (15 mL) was added LiOH.H2O (0.65 g), and the resulting mixture stirred at RT overnight. The reaction mixture was then acidified with citric acid (2.99 g) in H2O (10 mL), and the solvent removed in vacuo. The resulting light orange solid was stirred in H2O for 30 min, filtered, washed with H2O, and dried to obtain 4-[4-(4-iodobenzotriazol-1-yl)-pyrimidin-2-ylamino]-cyclohexanecarboxylic acid (2.1 g, 87%) as a light orange powder. Mp=252-254° C.

Provenance & Evidence