Methyl morpholine oxide → HCID 58307569, compound

Participants

Reaction Steps

N-methylmorpholine N-oxide (2.7 g, 23 mmol) was added to a suspension of Compound 3 (4.55 g, 23 mmol) in 50 mL of acetone/water (10:1) at 0° C. After 7 min OsO4 (1.048 mL, 0.092 mmol) was added slowly. The solution was stirred 36 h at room temperature, and then the solvent was evaporated in vacuo. It was acidified with dilute hydrochloric acid and extracted with ethyl acetate. The filtrate was concentrated to yield the corresponding compound 4 (5.1 g, yield 85.2%).

Provenance & Evidence