Methanol → HCID 59401903, compound

Participants

Reaction Steps

To a solution of (2S,3S)-(2-Methyl-pyrrolidin-1-yl)-pyrrolidin-3-yl-methanone (2.3 mmol, as obtained above) in dry THF (6 mL) was added drop-wise 2 M solution of BH3SMe2 in THF (2M in THF, 5 mL, 10 mmol, 4 equiv.). The mixture was refluxed for 2 h. The solution was cooled to rt, 5 mL of methanol was added and stirred for 2 h at r.t. The solvent was evaporated to dryness to obtain 0.46 g of the title product as a semi-solid. LC/MS showed the molecular ion peak of the title compound at 169 (M+H) with a retention time of 1.742 min.

Provenance & Evidence