HCID 59401909, compound → HCID 59401910, compound

Participants

Reaction Steps

A solution of (2S,3R)-2-methyl-1-[1-(3-methyl-4-nitro-phenyl)-pyrrolidin-3-yl-methyl]-pyrrolidine (0.3 g, 1 mmol) in MeOH (15 mL) was deaerated and nitrogen was introduced. To this solution was added Pd—C (10%, 30 mg). This mixture was stirred under H2 atmosphere at r.t. overnight. TLC (10% MeOH in DCM) and LC/MS showed the reaction was complete, product peak was observed at t=1.458 min, m/z: 274 (M). The mixture was passed through a Celite pad, rinsed with methanol. The filtrate was concentrated to dryness, and further dried under high vacuum to yield the title compound as a reddish brown liquid after drying under high vacuum.

Provenance & Evidence