6-(1H-Pyrrol-1-yl)nicotinic acid → N-{2-Methyl-4-[3-(2-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-phenyl}-6-pyrrol-1-yl-nicotinamide

HRID 1516545Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1516545
[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][N:14]3[CH2:18][CH2:17][CH2:16][CH:15]3[CH3:19])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH2:20].[N:21]1([C:26]2[CH:34]=[CH:33][C:29]([C:30](O)=[O:31])=[CH:28][N:27]=2)[CH:25]=[CH:24][CH:23]=[CH:22]1>>[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][N:14]3[CH2:18][CH2:17][CH2:16][CH:15]3[CH3:19])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH:20][C:30](=[O:31])[C:29]1[CH:33]=[CH:34][C:26]([N:21]2[CH:22]=[CH:23][CH:24]=[CH:25]2)=[N:27][CH:28]=1

Komponenten

3

Edukt 2

HCID 27641006-(1H-Pyrrol-1-yl)nicotinic acidHCID 684676422-Methyl-4-[3-(2-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-phenylamine

Produkt 1

HCID 25265669N-{2-Methyl-4-[3-(2-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-phenyl}-6-pyrrol-1-yl-nicotinamide

Versuchsvorschrift

The title compound was prepared in a manner substantially the same as Example 1 by coupling 2-methyl-4-[3-(2-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-phenylamine with 6-pyrrol-1-yl-nicotinic acid. MS: 444.5 (M+H).

Quellen und Nachweise

ORD-Eintrag
ord-b52d0cd7e07d42c7ad2bc31ca698c9bc
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08227504B2

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