2,5-Dioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-8-carboxylic acid → HCID 25263721, compound
Reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][N:14]3[CH2:18][CH2:17][CH2:16][CH:15]3[CH3:19])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH2:20].[O:21]=[C:22]1[NH:28][C:27]2[CH:29]=[C:30]([C:33](O)=[O:34])[CH:31]=[CH:32][C:26]=2[C:25](=[O:36])[NH:24][CH2:23]1>>[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][N:14]3[CH2:18][CH2:17][CH2:16][CH:15]3[CH3:19])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH:20][C:33]([C:30]1[CH:31]=[CH:32][C:26]2[C:25](=[O:36])[NH:24][CH2:23][C:22](=[O:21])[NH:28][C:27]=2[CH:29]=1)=[O:34]Participants
3
Procedure
The title compound was prepared in a manner substantially the same as Example 1 by coupling 2-methyl-4-[3-(2-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-phenylamine with 2,5-dioxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-8-carboxylic acid. MS: 476.3 (M+H).
Sources & evidence
- ORD record
- ord-4cfa75a2af2b41fa8420b3c0596071bb
- Source dataset
- uspto-grants-2012_07
- Patent number
- US08227504B2
Reaction notes
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