6-Methoxy-1-benzofuran-2-carboxylic acid → 6-Methoxy-benzofuran-2-carboxylic acid {2-methyl-4-[3-(2-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-phenyl}-amide

HRID 1516555Notes

Reaction equation

HRID 1516555 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][N:14]3[CH2:18][CH2:17][CH2:16][CH:15]3[CH3:19])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH2:20].[CH3:21][O:22][C:23]1[CH:34]=[CH:33][C:26]2[CH:27]=[C:28]([C:30](O)=[O:31])[O:29][C:25]=2[CH:24]=1>>[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][N:14]3[CH2:18][CH2:17][CH2:16][CH:15]3[CH3:19])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH:20][C:30]([C:28]1[O:29][C:25]2[CH:24]=[C:23]([O:22][CH3:21])[CH:34]=[CH:33][C:26]=2[CH:27]=1)=[O:31]

Participants

3

Reactant 2

HCID 9188636-Methoxy-1-benzofuran-2-carboxylic acidHCID 684676422-Methyl-4-[3-(2-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-phenylamine

Product 1

HCID 252637166-Methoxy-benzofuran-2-carboxylic acid {2-methyl-4-[3-(2-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-phenyl}-amide

Procedure

The title compound was prepared in a manner substantially the same as Example 1 by coupling 2-methyl-4-[3-(2-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-phenylamine with 6-methoxy-benzofuran-2-carboxylic acid. MS: 448.5 (M+H).

Sources & evidence

ORD record
ord-0a0d19dd9b284c9b81380bb0b9bbeaed
Source dataset
uspto-grants-2012_07
Patent number
US08227504B2

Reaction notes

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