4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid → N-{2-Methyl-4-[3-(2-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-phenyl}-4-(3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl)-benzamide

HRID 1516558노트

반응식

HRID 1516558 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][N:14]3[CH2:18][CH2:17][CH2:16][CH:15]3[CH3:19])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH2:20].[CH3:21][C:22]1[CH2:26][C:25](=[O:27])[N:24]([C:28]2[CH:36]=[CH:35][C:31]([C:32](O)=[O:33])=[CH:30][CH:29]=2)[N:23]=1>>[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][N:14]3[CH2:18][CH2:17][CH2:16][CH:15]3[CH3:19])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH:20][C:32](=[O:33])[C:31]1[CH:35]=[CH:36][C:28]([N:24]2[C:25](=[O:27])[CH2:26][C:22]([CH3:21])=[N:23]2)=[CH:29][CH:30]=1

참가 물질

3

반응물 2

HCID 1090294-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acidHCID 684676422-Methyl-4-[3-(2-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-phenylamine

생성물 1

HCID 25265666N-{2-Methyl-4-[3-(2-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-phenyl}-4-(3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl)-benzamide

실험 절차

The title compound was prepared in a manner substantially the same as Example 1 by coupling 2-methyl-4-[3-(2-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-phenylamine with 4-(3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl)-benzoic acid. MS: 474.6 (M+H).

출처 및 근거

ORD 기록
ord-be5bc437e7dc4a77ba983a8a1c8756db
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08227504B2

반응 노트

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