3-Fluorobenzoyl chloride → HCID 59401907, compound

HRID 1516561Notes

Reaction equation

HRID 1516561 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][C@H:10]([CH2:13][N:14]3[CH2:18][CH2:17][CH2:16][C@@H:15]3[CH3:19])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH2:20].[F:21][C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=1)[C:25](Cl)=[O:26]>>[F:21][C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=1)[C:25]([NH:20][C:3]1[CH:4]=[CH:5][C:6]([N:8]2[CH2:12][CH2:11][C@H:10]([CH2:13][N:14]3[CH2:18][CH2:17][CH2:16][C@@H:15]3[CH3:19])[CH2:9]2)=[CH:7][C:2]=1[CH3:1])=[O:26]

Participants

3

Reactant 2

HCID 743763-Fluorobenzoyl chlorideHCID 59401910HCID 59401910, compound

Product 1

HCID 59401907HCID 59401907, compoundYield 39%

Procedure

The title compound was prepared in a manner substantially the same as example 20 by coupling (2S,3R)-2-methyl-4-[3-(2-methyl-pyrrolidin-1-yl-methyl)-pyrrolidin-1-yl]-phenylamine with 3-fluoro-benzoyl chloride in 39% yield.

Sources & evidence

ORD record
ord-00a0dc9e3195498e91105512e8cd8194
Source dataset
uspto-grants-2012_07
Patent number
US08227504B2

Reaction notes

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