3-Furoyl chloride → HCID 25265671, compound

HRID 1516562Notes

Reaction equation

HRID 1516562 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][C@H:10]([CH2:13][N:14]3[CH2:18][CH2:17][CH2:16][C@@H:15]3[CH3:19])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH2:20].[O:21]1[CH:25]=[CH:24][C:23]([C:26](Cl)=[O:27])=[CH:22]1>>[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][C@H:10]([CH2:13][N:14]3[CH2:18][CH2:17][CH2:16][C@@H:15]3[CH3:19])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH:20][C:26]([C:23]1[CH:24]=[CH:25][O:21][CH:22]=1)=[O:27]

Participants

3

Reactant 2

HCID 27761233-Furoyl chlorideHCID 59401910HCID 59401910, compound

Product 1

HCID 25265671HCID 25265671, compoundYield 35%

Procedure

The title compound was prepared in a manner substantially the same as example 20 by coupling (2S,3R)-2-methyl-4-[3-(2-methyl-pyrrolidin-1-yl-methyl)-pyrrolidin-1-yl]-phenylamine with 3-furoyl chloride in 35% yield.

Sources & evidence

ORD record
ord-b689474b540c4959871e283179229293
Source dataset
uspto-grants-2012_07
Patent number
US08227504B2

Reaction notes

Loading…