3,5-Dimethylisoxazole-4-carbonyl Chloride → HCID 25263576, compound

HRID 1516563Notes

Reaction equation

HRID 1516563 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][C@H:10]([CH2:13][N:14]3[CH2:18][CH2:17][CH2:16][C@@H:15]3[CH3:19])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH2:20].[CH3:21][C:22]1[C:26]([C:27](Cl)=[O:28])=[C:25]([CH3:30])[O:24][N:23]=1>>[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][C@H:10]([CH2:13][N:14]3[CH2:18][CH2:17][CH2:16][C@@H:15]3[CH3:19])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH:20][C:27]([C:26]1[C:22]([CH3:21])=[N:23][O:24][C:25]=1[CH3:30])=[O:28]

Participants

3

Reactant 2

HCID 27362653,5-Dimethylisoxazole-4-carbonyl ChlorideHCID 59401910HCID 59401910, compound

Product 1

HCID 25263576HCID 25263576, compoundYield 50%

Procedure

The title compound was prepared in a manner substantially the same as example 20 by coupling (2S,3R)-2-methyl-4-[3-(2-methyl-pyrrolidin-1-yl-methyl)-pyrrolidin-1-yl]-phenylamine with 3,5-dimethyIsoxazole-4-carbonyl chloride in 50% yield.

Sources & evidence

ORD record
ord-ca8ced658aa540e7b19e22ebd5f26006
Source dataset
uspto-grants-2012_07
Patent number
US08227504B2

Reaction notes

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