反应详情

(2,3-dimethylphenyl)(1-trityl-1H-imidazol-5-yl)methanone, (Intermediate 3) (1.2 g, 2.7 mmol) in dichloromethane (30 mL) was treated with phenyl-magnesium bromide (1.35 mL, 4.05 mmol, 3 M in THF) 0° C. and then stirred for 16 h at rt. The mixture was quenched with water (10 mL) and a saturated solution of ammonium chloride (10 mL). The residue was isolated in a typical aqueous workup to give (2,3-dimethylphenyl)(phenyl)(1-trityl-1H-imidazol-5-yl)methanol, (Intermediate 4), (crude).

1. customThe mixture was quenched with water (10 mL)
2. customThe residue was isolated in a typical aqueous workup