反应详情

A solution of phenyl-o-tolyl-(3-trityl-3H-imidazol-4-yl)-methanone (500 mg, 1.2 mmol) in dichloromethane (25 mL) at rt was treated with o-tolyl magnesium bromide (1.2 mL, 2.4 mmol, 2M in ether) and the reaction mixture was then stirred at rt for 16 h. The mixture was quenched with water (50 mL) and a sat. solution of ammonium chloride (20 mL). The residue was isolated in a typical aqueous to give phenyl-o-tolyl-(3-trityl-3H-imidazol-4-yl)-methanol, (Intermediate 4) (620 mg, crude).

1. customThe mixture was quenched with water (50 mL)
2. customThe residue was isolated in a typical aqueous