HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → Ethyl 3'-bromo-4'-[3-(tert-butyldimethylsilanyloxy)propoxy]biphenyl-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (3-Bromopropoxy)(tert-butyl)dimethylsilane | HCID 607486 | — |
| Reactant | Ethyl 3'-bromo-4'-hydroxybiphenyl-4-carboxylate | HCID 16657517 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 3'-bromo-4'-[3-(tert-butyldimethylsilanyloxy)propoxy]biphenyl-4-carboxylate | HCID 66671827 | 64.3% |
Reaction Steps
In a manner similar to that of Example 2a, by reacting 3 g of ethyl 3′-bromo-4′-hydroxy-biphenyl-4-carboxylate (9.3 mmol) in 100 mL of dimethylformamide with 448 mg (11 mmol) of sodium hydride and 2.6 mL of 1-bromo-3-(tert-butyldimethylsilanyloxy)propane (11 mmol). 2.95 g of ethyl 3′-bromo-4′-[3-(tert-butyldimethylsilanyloxy)propoxy]biphenyl-4-carboxylate are obtained (yield=64%) in the form of an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08227507B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-f0ec41cf037942b9ac13612a7213e8b3 |
| Source note | uspto-grants-2012_07 |