HCID 67411141, compound → HCID 73230097, compound

Participants

Reaction Steps

The title compound was prepared from 2-(5-bromo-2-fluorophenyl)-4-hydroxy-6,7-dihydro-5H-cyclopentapyrimidine and intermediate 24 following the procedure (Steps 13-16) reported for the preparation of N-[17-[2-(3-isopropylpyrazol-1-yl)-7-methoxy-8-methylquinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo-[13.3.0.04,6]octadec-7-ene-4-carbonyl](dimethylamino)sulfonamide (29): m/z=748 (M+H)+. 1H NMR (CDCl3): 1.13-1.51 (m, 4H), 1.54-1.95 (m, 4H), 2.08-2.45 (m, 5H), 2.50-2.65 (m, 2H), 2.80-3.15 (m, 14H), 3.22-3.40 (m, 2H), 4.60 (t, J=12.4 Hz, 1H), 5.05 (t, J=9.9 Hz, 1H), 5.60-5.75 (m, 2H), 6.24 (s, 1H), 7.05 (t, J=9.5 Hz, 1H), 7.48-7.55 (m, 1H), 8.10-8.18 (m, 1H), 10.6 (br s, 1H).

Provenance & Evidence