HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1516673Generated: November 2, 2026
Methanol → 2-(4-Fluorobenzamido)-4-methoxy-3-methylbenzoic acid
https://huagongshe.com/reaction/1516673
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 2-(4-Fluorobenzoylamino)-4-methoxy-3-methyl-benzoic acid methyl ester | HCID 59165419 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(4-Fluorobenzamido)-4-methoxy-3-methylbenzoic acid | HCID 59165475 | 101.4% |
Reaction Steps
LiOH (1M, 4 mL) was added to a solution of 2-(4-fluoro-benzoylamino)-4-methoxy-3-methyl-benzoic acid methyl ester (41) (870 mg, 2.7 mmol), in tetrahydrofuran (15 ml), water (7.5 ml) and methanol (7.5 ml). The mixture was heated to 50° C. for 4 h. Water (30 ml) was then added and the volume reduced to half. Acidification with acetic acid followed by filtration gave pure title compound (830 mg, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08227407B2 |
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| Source dataset | uspto-grants-2012_07 |
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| ORD ID | ord-4990763442f0402cae985ba07d83b90a |
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| Source note | uspto-grants-2012_07 |
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