反应详情

100 mg (0.22 mmol) of 7-cyclopentyl-6-{hydroxy[4-(trifluoromethyl)phenyl]methyl}-5-methoxy-2,2-dimethyl-2,3-dihydro-4H-chromen-4-one (Example 7A) are dissolved in 5 ml of dichloromethane, 194 mg (2.23 mmol) of manganese(IV) oxide are added and the mixture is stirred at room temperature overnight. The mixture is filtered through a layer of silica gel, the filter cake is washed thoroughly with ethyl acetate and the filtrate is concentrated to dryness. The crude product is chromatographed on silica gel (mobile phase: cyclohexane/ethyl acetate 10:1). This gives 82.5 mg (83% of theory) of the title compound.

1. filtrationThe mixture is filtered through a layer of silica gel
2. washthe filter cake is washed thoroughly with ethyl acetate
3. concentrationthe filtrate is concentrated to dryness
4. customThe crude product is chromatographed on silica gel (mobile phase: cyclohexane/ethyl acetate 10:1)