反应详情

A mixture of 3-fluoro-4-nitrotoluene (10 g, 1 eq) and potassium permanganate (25.5 g, 2.5 eq) in water (1 l) is heated to reflux for 6 hours then cooled down to ambient temperature. The mixture is filtered on celite and the aqueous phase is washed twice with diethyl ether (2×300 ml). The aqueous phase is acidified with an aqueous solution of concentrated hydrochloric acid (12N) then concentrated under reduced pressure at 40° C. to a volume of approximately 300 ml. The precipitate formed is filtered then washed with petroleum ether and dried in order to produce the expected compound in the form of a white solid (6.9 g; 58% yield).

1. temperatureis heated
2. temperatureto reflux for 6 hours
3. filtrationThe mixture is filtered on celite
4. washthe aqueous phase is washed twice with diethyl ether (2×300 ml)
5. concentrationthen concentrated under reduced pressure at 40° C. to a volume of approximately 300 ml
6. customThe precipitate formed
7. filtrationis filtered
8. washthen washed with petroleum ether
9. customdried in order