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Quinuclidine, 3-amino-, dihydrochloride → N-(1-Azabicyclo[2.2.2]oct-3-yl)-7-quinolinecarboxamide hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Quinuclidine, 3-amino-, dihydrochloride | HCID 197853 | — |
| 反応物 | Quinoline-7-carboxylic acid | HCID 599475 | — |
| 生成物 | N-(1-Azabicyclo[2.2.2]oct-3-yl)-7-quinolinecarboxamide hydrochloride | HCID 69249623 | 71.1% |
反応手順
Prepared in analogy to the method for Example 1 starting from 183 mg of quinoline-7-carboxylic acid (Seibert et al. J. Am. Chem. Soc. 1946, 68, 2721) and 200 mg of 3-aminoquinuclidine dihydrochloride. 227 mg (71% yield) of the hydrochloride were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08227598B2 |
| 出典データセット | uspto-grants-2012_07 |
| ORD ID | ord-c04e3233f8004ca68f8e93e87f2ad86c |
| 出典メモ | uspto-grants-2012_07 |