反应详情

Hydrazine sulphate salt (51 g) was suspended in water (250 ml), heated to reflux and bromomaleic anhydride (90.38 g) was added dropwise. The mixture was heated at reflux for 4 hours then cooled to room temperature. The reaction was repeated with 29 g hydrazine sulphate, 53 g bromomaleic anhydride and 130 ml water. The precipitates were collected by filtration, washed with water and acetone and dried as a combined batch in vacuo to afford 4-bromo-1,2-dihydro-3,6-pyridazinedione as a white solid (113 g).

1. temperatureheated
2. temperatureto reflux
3. temperatureThe mixture was heated
4. temperatureat reflux for 4 hours
5. filtrationThe precipitates were collected by filtration
6. washwashed with water and acetone
7. customdried as a combined batch in vacuo