HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Cesium carbonate → [6-(2-Benzyloxy-ethylamino)-3-methyl-5-(3-trifluoromethyl-phenyl)-pyridin-2-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Cesium carbonate | HCID 10796 | — |
| Edukt | 2-(Benzyloxy)ethanamine | HCID 533868 | — |
| Edukt | Binap, (A+-)- | HCID 634876 | — |
| Edukt | [6-Chloro-3-methyl-5-(3-trifluoromethyl-phenyl)-pyridin-2-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone | HCID 44547211 | — |
| Katalysator | palladium(II) acetate | HCID 167845 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Produkt | [6-(2-Benzyloxy-ethylamino)-3-methyl-5-(3-trifluoromethyl-phenyl)-pyridin-2-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone | HCID 67025369 | — |
Reaktionsschritte
In analogy to the procedure described for the preparation of example 6, [6-chloro-3-methyl-5-(3-trifluoromethyl-phenyl)-pyridin-2-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (example 3) was reacted with 2-benzyloxy-ethylamine, [rac]-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl, palladium(II) acetate and cesium carbonate in toluene at reflux to give the title compound as yellow oil. MS: 567.4 (MH+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08227613B2 |
| Quelldatensatz | uspto-grants-2012_07 |
| ORD ID | ord-d8c0b75569b34ff8922eb581b7dd9b06 |
| Quellennotiz | uspto-grants-2012_07 |