Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(1-Pyrrolidinyl)piperidine → [6-Chloro-3-methyl-5-(3-trifluoromethyl-phenyl)-pyridin-2-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(1-Pyrrolidinyl)piperidine | HCID 78703 | — |
| 반응물 | 3-Methyl-5-(3-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid | HCID 57441124 | — |
| 반응물 | 6-Chloro-3-methyl-5-(3-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid methyl ester | HCID 57441125 | — |
| 반응물 | 6-Chloro-3-methyl-5-(3-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid | HCID 86637420 | — |
| 생성물 | [6-Chloro-3-methyl-5-(3-trifluoromethyl-phenyl)-pyridin-2-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone | HCID 44547211 | — |
반응 단계
In analogy to the procedure described for example 1, 6-chloro-3-methyl-5-(3-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid [prepared from 6-chloro-3-methyl-5-(3-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid methyl ester (intermediate 2) by saponification in analogy to the procedure described for intermediate 1B] was reacted with 4-pyrrolidin-1-yl-piperidine to give the title compound as light brown solid. MS: 452.1 (MH+, 1Cl).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08227613B2 |
| 출처 데이터셋 | uspto-grants-2012_07 |
| ORD ID | ord-62cfcf0d424047f9a85b9bde9e2565c1 |
| 출처 메모 | uspto-grants-2012_07 |