HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-(1-Pyrrolidinyl)piperidine → [4-Chloro-3-methyl-5-(3-trifluoromethyl-phenyl)-pyridin-2-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-(1-Pyrrolidinyl)piperidine | HCID 78703 | — |
| Edukt | 3-Methyl-5-(3-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid | HCID 57441124 | — |
| Edukt | 4-Chloro-3-methyl-5-(3-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid methyl ester | HCID 67025389 | — |
| Edukt | 4-Chloro-3-methyl-5-(3-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid | HCID 86637421 | — |
| Produkt | [4-Chloro-3-methyl-5-(3-trifluoromethyl-phenyl)-pyridin-2-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone | HCID 57441144 | — |
Reaktionsschritte
In analogy to the procedure described for example 1, 4-chloro-3-methyl-5-(3-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid [prepared from 4-chloro-3-methyl-5-(3-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid methyl ester (intermediate 3) by saponification in analogy to the procedure described for intermediate 1B] was reacted with 4-pyrrolidin-1-yl-piperidine to give the title compound as colorless solid. MS: 452.1 (MH+, 1Cl).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08227613B2 |
| Quelldatensatz | uspto-grants-2012_07 |
| ORD ID | ord-81be8d1fbdd3415c80457870a20c52a3 |
| Quellennotiz | uspto-grants-2012_07 |