3-Methyl-5-(3-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid → benzoic acid (S)-1-{1-[3-methyl-5-(3-trifluoromethyl-phenyl)-pyridine-2-carbonyl]-piperidin-4-yl}-pyrrolidin-2-ylmethyl ester

Participants

Reaction Steps

In analogy to the procedures described for example 1 and for intermediate 1B, 3-methyl-5-(3-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid (intermediate 1B) was reacted with benzoic acid (S)-1-piperidin-4-yl-pyrrolidin-2-ylmethyl ester (intermediate 6) to give benzoic acid (S)-1-{1-[3-methyl-5-(3-trifluoromethyl-phenyl)-pyridine-2-carbonyl]-piperidin-4-yl}-pyrrolidin-2-ylmethyl ester, which was subsequently saponified to give the title compound as light brown solid. MS: 448.1 (MH+).

Provenance & Evidence