HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pyridinylboronic acid → [5-Methyl-3-(3-trifluoromethyl-phenyl)-[2,3']bipyridinyl-6-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pyridinylboronic acid | HCID 2734378 | — |
| Reactant | [6-Chloro-3-methyl-5-(3-trifluoromethyl-phenyl)-pyridin-2-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone | HCID 44547211 | — |
| Reactant | HCID 57441128 | HCID 57441128 | — |
| Product | [5-Methyl-3-(3-trifluoromethyl-phenyl)-[2,3']bipyridinyl-6-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone | HCID 44547361 | — |
Reaction Steps
In analogy to the procedure described for the preparation of intermediate 5C, [6-chloro-3-methyl-5-(3-trifluoromethyl-phenyl)-pyridin-2-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (example 3) was reacted with pyridine-3-yl-boronic acid to give the title compound as colorless oil. MS: 495.3 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08227613B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-c998738bc1ec4779b980b08f50fc15b3 |
| Source note | uspto-grants-2012_07 |