Sodium Methoxide → HCID 57441154, compound

HRID 1517090Notes

Reaction equation

HRID 1517090 reaction equation
[Cl:1][C:2]1[C:3]([C:19]([N:21]2[CH2:26][CH2:25][CH:24]([N:27]3[CH2:31][CH2:30][CH2:29][CH2:28]3)[CH2:23][CH2:22]2)=[O:20])=[N:4][C:5](Cl)=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[CH:7]=1.[CH3:32][O-:33].[Na+]>CO>[Cl:1][C:2]1[C:3]([C:19]([N:21]2[CH2:26][CH2:25][CH:24]([N:27]3[CH2:31][CH2:30][CH2:29][CH2:28]3)[CH2:23][CH2:22]2)=[O:20])=[N:4][C:5]([O:33][CH3:32])=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 58016712HCID 58016712, compound

Product 1

HCID 57441154HCID 57441154, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In analogy to the procedure described for the preparation of example 8, [3,6-dichloro-5-(3-trifluoromethyl-phenyl)-pyridin-2-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (example 21) was reacted with sodium methoxide in methanol at 50° C. to give the title compound as light yellow oil. MS: 468.3 (MH+, 1Cl).

Sources & evidence

ORD record
ord-74e512f245fd474cac3bc0bc606ead9e
Source dataset
uspto-grants-2012_07
Patent number
US08227613B2

Reaction notes

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