HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-1,2,4-Triazole → [3-Methyl-6-[1,2,4]triazol-1-yl-5-(3-trifluoromethyl-phenyl)-pyridin-2-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-1,2,4-Triazole | HCID 9257 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | [6-Chloro-3-methyl-5-(3-trifluoromethyl-phenyl)-pyridin-2-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone | HCID 44547211 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | [3-Methyl-6-[1,2,4]triazol-1-yl-5-(3-trifluoromethyl-phenyl)-pyridin-2-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone | HCID 57441120 | — |
Reaction Steps
In analogy to the procedure described for the preparation of example 20, [6-chloro-3-methyl-5-(3-trifluoromethyl-phenyl)-pyridin-2-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (example 3) was reacted with 1H-[1,2,4]triazole and sodium hydride in 1-methyl-pyrrolidin-2-one at reflux to give the title compound as colorless solid. MS: 485.3 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08227613B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-6a2aa51f28134bc682e973936e6ec3b9 |
| Source note | uspto-grants-2012_07 |