HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → [5-(4-Fluoro-3-trifluoromethyl-phenyl)-3-methyl-pyridin-2-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-Fluoro-3-(trifluoromethyl)benzeneboronic acid | HCID 17750051 | — |
| Reactant | 3-Methyl-5-(3-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid methyl ester | HCID 57441123 | — |
| Reactant | [5-(3,4-Dichloro-phenyl)-3-methyl-pyridin-2-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone | HCID 58016731 | — |
| Catalyst | Palladium Chloride | HCID 24290 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | [5-(4-Fluoro-3-trifluoromethyl-phenyl)-3-methyl-pyridin-2-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone | HCID 57441158 | — |
Reaction Steps
In analogy to the procedure described for the preparation of intermediate 1A, (5-bromo-3-methyl-pyridin-2-yl)-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (see example 28) was reacted with 4-fluoro-3-trifluoromethyl-phenyl-boronic acid, (1,1′-bis-diphenylphosphino)-ferrocene)palladium-(II)dichloride (1:1 complex with CH2Cl2) and sodium carbonate in dioxane/water to give the title compound as brown amorphous solid. MS: 436.4 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08227613B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-e2b1f237bd6a42ee951eadb4e175be8b |
| Source note | uspto-grants-2012_07 |