反应详情

In analogy to the procedure described for the preparation of intermediate 10C, [6-(2-methoxy-pyrimidin-5-yl)-3-methyl-5-(3-trifluoromethyl-phenyl)-pyridin-2-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (example 44) was reacted with boron tribromide in dichloromethane to give the title compound as light yellow solid. MS: 512.2 (MH+).