1,4-Dioxane hydrochloride → HCID 57441169, compound

HRID 1517125Notes

Reaction equation

HRID 1517125 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:21]([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([F:31])([F:30])[F:29])[CH:23]=3)=[CH:20][C:19]([CH3:32])=[C:18]([C:33]([N:35]3[CH2:40][CH2:39][CH:38]([N:41]4[CH2:45][CH2:44][CH2:43][CH2:42]4)[CH2:37][CH2:36]3)=[O:34])[N:17]=2)=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.O1CCOCC1>CO>[CH3:32][C:19]1[CH:20]=[C:21]([C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([F:31])([F:29])[F:30])[CH:23]=2)[C:16]([C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[O:15])=[N:17][C:18]=1[C:33]([N:35]1[CH2:40][CH2:39][CH:38]([N:41]2[CH2:45][CH2:44][CH2:43][CH2:42]2)[CH2:37][CH2:36]1)=[O:34]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 57441168HCID 57441168, compound

Product 1

HCID 57441169HCID 57441169, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In analogy to the procedure described for the preparation of example 60, 4-[5-methyl-6-(4-pyrrolidin-1-yl-piperidine-1-carbonyl)-3-(3-trifluoromethyl-phenyl)-pyridine-2-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester (example 59) was reacted with HCl/dioxane in methanol to give the title compound as light yellow solid. MS: 530.2 (MH+).

Sources & evidence

ORD record
ord-993cefb8a349407b8504f2a57c1c1170
Source dataset
uspto-grants-2012_07
Patent number
US08227613B2

Reaction notes

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