Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Bicyclo(2.2.1)hept-5-ene-2-methanol | HCID 78946 | — |
| Reactant | 3-(3-Fluorophenyl)-2-propenoic acid | HCID 88606 | — |
| Catalyst | HCID 86657292 | HCID 86657292 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 86657293 | HCID 86657293 | 54% |
Reaction Steps
5 g (43 mmol) of 3-fluoro-cinnamic acid, 5.35 g (43 mmol) of 5-norbornene-2-methanol, and 0.21 g (0.02 eq.) of zirconium(IV) acetate hydroxide were added to 50 ml of toluene and stirred. The mixture was heated to 145° C. under N2 atmosphere and azeotropically refluxed for 24 hours. After the reaction, the mixture cooled down to room temperature and was added with 100 volume % of ethyl acetate. The resulting product was extracted by 1M HCl and washed again with water. The organic layer was dried with Na2SO4 and the solvent was evaporated out to give a highly viscous material. (Yield: 54%, Purity (GC): 73%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08231946B2 |
|---|
| Source dataset | uspto-grants-2012_07 |
|---|
| ORD ID | ord-b94072b79ad343a79d81f49c93c7f2b9 |
|---|
| Source note | uspto-grants-2012_07 |
|---|
