1-[4-(Isobutylamino)-3-nitrophenyl]ethanone → 1-[3-Amino-4-(isobutylamino)phenyl]ethanone

Beteiligte Stoffe

Reaktionsschritte

To a solution of 31.6 g (134 mM) of 1-[4-(isobutylamino)-3-nitrophenyl]-ethanone in 400 ml of methanol are added 3.2 g of 10% palladium-on-charcoal. The reaction medium is then placed under a hydrogen atmosphere at ambient pressure with vigorous stirring for 1 hour. The reaction medium is filtered through Celite and the solvent is evaporated off under vacuum to give 27.6 g of 1-[3-amino-4-(isobutylamino)phenyl]ethanone in quantitative yield, in the form of an oil.

Herkunft & Nachweise