p-Aminopropiophenone → N-[4-(1-oxopropyl)phenyl]acetamide

HRID 1517190Notes

Reaction equation

HRID 1517190 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:11])[CH2:9][CH3:10])=[CH:4][CH:3]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>C1(C)C=CC=CC=1>[C:8]([C:5]1[CH:4]=[CH:3][C:2]([NH:1][C:12](=[O:14])[CH3:13])=[CH:7][CH:6]=1)(=[O:11])[CH2:9][CH3:10]

Participants

4

Reactant 2

HCID 6270p-AminopropiophenoneHCID 7918Acetic Anhydride

Product 1

HCID 85655N-[4-(1-oxopropyl)phenyl]acetamide

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
60 °C

Procedure

To 400 ml of toluene are added 30 g of 1-(4-aminophenyl)propan-1-one and 38 ml (402 mM) of acetic anhydride. The reaction medium is heated at 60° C. with stirring for 1 hour. A solid precipitates out. After filtration and washing with toluene, 37.9 g of N-(4-propanoylphenyl)acetamide are obtained in the form of a white powder.

Workup

  1. customA solid precipitates out
  2. filtrationAfter filtration
  3. washwashing with toluene, 37.9 g of N-(4-propanoylphenyl)acetamide
  4. customare obtained in the form of a white powder

Sources & evidence

ORD record
ord-85a8dd339edc480fa1207355c3f76368
Source dataset
uspto-grants-2012_07
Patent number
US08232272B2

Reaction notes

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