Hydrochloric Acid → HCID 67356528, compound

Participants

Reaction Steps

Ethanolic hydrogen chloride (1M, 420 mL) was added dropwise to a solution of aminoacetaldehyde diethyl acetal (55.1 g, 0.14 mol) and the compound isolated in Step 2 (101 g, 0.41 mol) in ethanol (1500 mL). This mixture was stirred at room temperature for 16 hours, and then evaporated under reduced pressure. The resulting solid was recrystalised from ether to give [(S)-4-(tert-butyl-dimethyl-silanyloxy)-4,5-dihydro-3H-pyrrol-2-yl]-(2,2-diethoxy-ethyl)-amine as a solid (201 g, 78%).

Provenance & Evidence