HRID1517223

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID5234

Sodium chloride

ClNa

2 次

HCID6212

Chloroform

CHCl3

2 次

HCID6314

Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, monohydrochloride

C14H23ClN2O

结构：CCCCC(CC)COC(=O)CC(C(=O)OCC(CC)CCCC)S(=O)(=O)O.[Na]

HCID9955175

未命名化合物

PRODUCTS

生成物

结构：CCCCC(CC)COC(=O)CC(C(=O)OCC(CC)CCCC)S(=O)(=O)O.CCN(CC)CC(=O)Nc1c(C)cccc1C

HCID17755878

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Lidocaine hydrochloride (0.0188 mol) was dissolved in 50 mL methanol and sodium docusate [bis(2-ethylhexyl)sulfosuccinate sodium salt] (0.0188 mol) was dissolved in 50 mL. The two solutions were combined and stirred for two hours, during this time a white precipitate (NaCl) formed. The methanol was removed by rotary evaporation which leaves a white sticky solid. To this solid, 150 mL of chloroform was added. A portion of the product dissolved the chloroform while the byproduct (NaCl) remained as a suspended solid. The NaCl was removed by filitration, and the solvent was removed by rotary evaporation. The product, lidocaine docusate, is a colorless syrup and is dried under high vacuum. 1H and 13C NMR (CDCl3) were obtained.

WORKUP

后处理

customformed
customThe methanol was removed by rotary evaporation which
customleaves a white sticky solid
customThe NaCl was removed by filitration
customthe solvent was removed by rotary evaporation
customis dried under high vacuum
custom1H and 13C NMR (CDCl3) were obtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-78cd1f5ba64544ea9ff536906c2385a6
来源数据集: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08232265B2
来源说明: uspto-grants-2012_07

反应 SMILES

[CH3:1][CH2:2][N:3]([CH2:6][C:7]([NH:9][C:10]1[C:11]([CH3:17])=[CH:12][CH:13]=[CH:14][C:15]=1[CH3:16])=[O:8])[CH2:4][CH3:5].Cl.[Na].[CH3:20][CH2:21][CH2:22][CH2:23][CH:24]([CH2:27][O:28][C:29]([CH2:31][CH:32]([S:44]([OH:47])(=[O:46])=[O:45])[C:33]([O:35][CH2:36][CH:37]([CH2:40][CH2:41][CH2:42][CH3:43])[CH2:38][CH3:39])=[O:34])=[O:30])[CH2:25][CH3:26].[Na+].[Cl-].C(Cl)(Cl)Cl>CO>[CH3:5][CH2:4][N:3]([CH2:6][C:7]([NH:9][C:10]1[C:15]([CH3:16])=[CH:14][CH:13]=[CH:12][C:11]=1[CH3:17])=[O:8])[CH2:2][CH3:1].[CH3:20][CH2:21][CH2:22][CH2:23][CH:24]([CH2:27][O:28][C:29]([CH2:31][CH:32]([S:44]([OH:47])(=[O:46])=[O:45])[C:33]([O:35][CH2:36][CH:37]([CH2:40][CH2:41][CH2:42][CH3:43])[CH2:38][CH3:39])=[O:34])=[O:30])[CH2:25][CH3:26]