Zantac → Ranitidine docusate

참여 물질

반응 조건

반응 단계

In a reaction vessel charged with a magnetic stirbar, 2.50 g (7.12 mmol) of Ranitidine hydrochloride was dissolved in approximately 25 mL of deionized water. In a separate reaction vessel, similarly charged with a stirbar, 3.17 g (7.12 mmol) of sodium docusate was dissolved/suspended in 25 mL of warm, deionized water. To the latter solution was added in one portion the aqueous solution of sodium docusate. The deep orange-brown milieu was stirred overnight, after which time the aqueous system was repeatedly extracted with 100 mL portions of chloroform. Emulsification of the two phases was quite pronounced, so each time the system was heated to about 60 ° C., then allowed to cool and settle for 5-7 days, after which point the dark chloroform phase was separated, dried over anhydrous MgSO4, filtered, and rotary evaporated to yield a viscous, deep brown-orange oil (Ranitidine docusate). The two ions have known histamine H2-receptor antagonist and an emollient properties, respectively.

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