化工社化工社 化学情報印刷レポート · 研究参考用
Diisopropylethylamine → 2,6-Dichloro-N-(4-chloro-3-(2-(2-(dimethylamino)ethylamino)-8-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-isonicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 2,6-Dichloroisonicotinic acid | HCID 94830 | — |
| 反応物 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 反応物 | 6-(5-amino-2-chlorophenyl)-2-(2-(dimethylamino)ethylamino)-8-methoxypyrido[2,3-d]pyrimidin-7(8H)-one | HCID 58478358 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2,6-Dichloro-N-(4-chloro-3-(2-(2-(dimethylamino)ethylamino)-8-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-isonicotinamide | HCID 44464375 | — |
反応手順
To a solution of 2,6-dichloroisonicotinic acid (0.37 g) in 10 ml THF was added diisopropylethylamine (0.449 ml) followed by HATU (0.733 g). After 10 min 1 ml DCM and 2 ml DMF were added. Then 6-(5-amino-2-chlorophenyl)-2-(2-(dimethylamino)ethylamino)-8-methoxypyrido[2,3-d]pyrimidin-7(8H)-one (0.5 g) was added as solution in THF (10 ml) with 1 ml DCM and 2 ml DMF. The reaction was stirred at r.t. for 1 h. The reaction mixture was diluted with 10 ml DCM, treated with 5 ml methanol and evaporated on 15 g alox (neutral).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08232283B2 |
| 出典データセット | uspto-grants-2012_07 |
| ORD ID | ord-8a8f3af0fce64498bdf44103188dedd0 |
| 出典メモ | uspto-grants-2012_07 |