4-[(1-Methyl-1H-pyrazol-3-yl)amino]quinazolin-6-ol → 5-chloro-6-({4-[(1-methyl-1H-pyrazol-3-yl)amino]quinazolin-6-yl}oxy)pyridin-3-ol

HRID 1517274ノート

反応式

HRID 1517274 の反応式
[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([OH:18])[CH:16]=3)[N:11]=[CH:10][N:9]=2)=[N:3]1.[Cl:19][C:20]1[C:21](F)=[N:22][CH:23]=[C:24]([O:26]CCC2OCCO2)[CH:25]=1>>[Cl:19][C:20]1[CH:25]=[C:24]([OH:26])[CH:23]=[N:22][C:21]=1[O:18][C:15]1[CH:16]=[C:17]2[C:12](=[CH:13][CH:14]=1)[N:11]=[CH:10][N:9]=[C:8]2[NH:7][C:4]1[CH:5]=[CH:6][N:2]([CH3:1])[N:3]=1

参加物

3

反応物 2

HCID 231603824-[(1-Methyl-1H-pyrazol-3-yl)amino]quinazolin-6-olHCID 684276893-Chloro-5-[2-(1,3-dioxolan-2-yl)ethoxy]-2-fluoropyridine

生成物 1

HCID 684297045-chloro-6-({4-[(1-methyl-1H-pyrazol-3-yl)amino]quinazolin-6-yl}oxy)pyridin-3-ol

実験手順

Using 4-[(1-methyl-1H-pyrazol-3-yl)amino]quinazolin-6-ol and 3-chloro-5-[2-(1,3-dioxolan-2-yl)ethoxy]-2-fluoropyridine, and in the same manner as in Example 6-2) and 6-3) or according to a method similar to it or according to a combination thereof with an ordinary method, 5-chloro-6-({4-[(1-methyl-1H-pyrazol-3-yl)amino]quinazolin-6-yl}oxy)pyridin-3-ol (738 mg) was obtained as a pale yellow amorphous solid.

出典と根拠

ORDレコード
ord-6321d73cd4524d5b88fb9dffedd56f2b
出典データセット
uspto-grants-2012_07
特許番号
US08232284B2

反応ノート

読み込み中…