HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Pyrrolidine → N-(5-methylpyrazin-2-yl)-6-{[5-(2-pyrrolidin-1-ylethoxy)pyridin-2-yl]oxy}quinazoline-4-amine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Pyrrolidine | HCID 31268 | — |
| Edukt | 5-(2,2-Diethoxyethoxy)-2-fluoropyridine | HCID 68429706 | — |
| Edukt | 4-((5-Methylpyrazin-2-yl)amino)quinazolin-6-ol | HCID 135618222 | — |
| Produkt | N-(5-methylpyrazin-2-yl)-6-{[5-(2-pyrrolidin-1-ylethoxy)pyridin-2-yl]oxy}quinazoline-4-amine | HCID 59508903 | — |
Reaktionsschritte
The compound of Example 38 was obtained as follows: Using 4-[(5-methylpyrazin-2-yl)amino]quinazolin-6-ol, 5-(2,2-diethoxyethoxy)-2-fluoropyridine and pyrrolidine, and in the same manner as in Example 31 or according to a method similar to it or according to a combination thereof with an ordinary method, the entitled compound (11 mg) was obtained as a pale yellow solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08232284B2 |
| Quelldatensatz | uspto-grants-2012_07 |
| ORD ID | ord-0fe534c237614144b48b83c2aaa344c1 |
| Quellennotiz | uspto-grants-2012_07 |