4-[(1-Methyl-1H-pyrazol-3-yl)amino]quinazolin-6-ol → 5-chloro-N-methyl-6-({4-[(1-methyl-1H-pyrazol-3-yl)amino]quinazolin-6-yl}oxy)-N-(2-pyrrolidin-1-ylethyl)nicotinamide

HRID 1517314Notes

Reaction equation

HRID 1517314 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([OH:18])[CH:16]=3)[N:11]=[CH:10][N:9]=2)=[N:3]1.[Cl:19][C:20]1[C:21](Cl)=[N:22][CH:23]=[C:24]([CH:36]=1)[C:25]([N:27]([CH3:35])[CH2:28][CH2:29][N:30]1[CH2:34][CH2:33][CH2:32][CH2:31]1)=[O:26]>>[Cl:19][C:20]1[C:21]([O:18][C:15]2[CH:16]=[C:17]3[C:12](=[CH:13][CH:14]=2)[N:11]=[CH:10][N:9]=[C:8]3[NH:7][C:4]2[CH:5]=[CH:6][N:2]([CH3:1])[N:3]=2)=[N:22][CH:23]=[C:24]([CH:36]=1)[C:25]([N:27]([CH3:35])[CH2:28][CH2:29][N:30]1[CH2:34][CH2:33][CH2:32][CH2:31]1)=[O:26]

Participants

3

Reactant 2

HCID 231603824-[(1-Methyl-1H-pyrazol-3-yl)amino]quinazolin-6-olHCID 551618625,6-dichloro-N-methyl-N-(2-pyrrolidin-1-ylethyl)nicotinamide

Product 1

HCID 426110345-chloro-N-methyl-6-({4-[(1-methyl-1H-pyrazol-3-yl)amino]quinazolin-6-yl}oxy)-N-(2-pyrrolidin-1-ylethyl)nicotinamide

Procedure

Using 4-[(1-methyl-1H-pyrazol-3-yl)amino]quinazolin-6-ol and 5,6-dichloro-N-methyl-N-(2-pyrrolidin-1-ylethyl)nicotinamide, and in the same manner as in Example 65 or according to a method similar to it or according to a combination thereof with an ordinary method, the entitled compound (99 mg) was obtained as a pale yellow amorphous solid.

Sources & evidence

ORD record
ord-8b3d48b3ffcf47a8ad823eb3c4382402
Source dataset
uspto-grants-2012_07
Patent number
US08232284B2

Reaction notes

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