(+-)-2-Butanol → 1-Phenylethanol

HRID 1517335Notes

Reaction equation

HRID 1517335 reaction equation
N1(C(N2CCC(OC3N=CN=C(N4[C:29]5[C:24](=[CH:25][C:26](S(C)(=O)=O)=[CH:27][CH:28]=5)[CH2:23][CH2:22]4)C=3)CC2)=O)C=CN=C1.CC([OH:38])CC>>[CH3:22][CH:23]([OH:38])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 6568(+-)-2-ButanolHCID 68561483HCID 68561483, compound

Product 1

HCID 74091-Phenylethanol

Procedure

The same reaction as in the method described in Example 9 was performed using the 1-(6-{[1-(1H-imidazol-1-ylcarbonyl)piperidin-4-yl]oxy}pyrimidin-4-yl)-5-(methylsulfonyl)indoline (150 mg, 0.311 mmol) produced in Reference Example 29 and, instead of 2-butanol, DL-1-phenylethanol (113 μL, 0.933 mmol) to obtain the title compound as white powder (60.5 mg, yield: 37%).

Workup

  1. customThe same reaction as in the method

Sources & evidence

ORD record
ord-7f86653ed3c44ffd9bf6634d086e0247
Source dataset
uspto-grants-2012_07
Patent number
US08232287B2

Reaction notes

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