4-Fluoro-3-methylbenzaldehyde → HCID 57695440, compound

HRID 1517354Notes

Reaction equation

[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:37])[N:7]([NH:30][C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[C:8]([C@H:12]([NH:15][CH2:16][CH2:17][CH2:18][N:19]3C(=O)C4C(=CC=CC=4)C3=O)[CH2:13][CH3:14])=[N:9]2)=[CH:4][CH:3]=1.[F:38][C:39]1[CH:46]=[CH:45][C:42]([CH:43]=O)=[CH:41][C:40]=1[CH3:47]>>[NH2:19][CH2:18][CH2:17][CH2:16][N:15]([CH2:43][C:42]1[CH:45]=[CH:46][C:39]([F:38])=[C:40]([CH3:47])[CH:41]=1)[C@@H:12]([C:8]1[N:7]([NH:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:6](=[O:37])[C:5]2[C:10](=[CH:11][C:2]([Cl:1])=[CH:3][CH:4]=2)[N:9]=1)[CH2:13][CH3:14]

Participants

Reactant 2

HCID 27348744-Fluoro-3-methylbenzaldehyde

HCID 67392045HCID 67392045, compound

Product 1

HCID 57695440HCID 57695440, compound

Procedure

This compound was synthesized as described in general procedure C except 2-{3-[(R)-1-(7-chloro-4-oxo-3-phenylamino-3,4-dihydro-quinazolin-2-yl)-propylamino]-propyl}-isoindole-1,3-dione was used instead of (R)-2-(3-(1-(7-chloro-4-oxo-3-(phenylamino)-3,4-dihydroquinazolin-2-yl)but-3-ynylamino)propyl)isoindoline-1,3-dione and 4-fluoro-3-methyl benzaldehyde was used instead of 4-methyl benzaldehyde. LCMS: m/e 508.04 [M+H].

Workup

customThis compound was synthesized

Sources & evidence

ORD record: ord-a056b12f72674fd5bf9b0f48703242e6
Source dataset: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08232285B2

Reaction notes

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