Lithium Hydroxide → HCID 178491758, compound

Participants

Reaction Steps

Ethyl 6-fluoro-2-((4-methoxy-N,2,6-trimethylphenylsulfonamido)methyl)-1H-benzo[d]imidazole-7-carboxylate (F-20) (2.4 mmol, 1 eq.) was hydrolysed with LiOH in THF/H2O (1:1). After the hydrolysis, the solvent was removed completely from the reaction mixture in vacuo and the residue was taken up in water and washed with ethyl acetate. The aqueous phase was adjusted to pH=4 and then extracted with ethyl acetate. The free acid 6-fluoro-2-((4-methoxy-N,2,6-trimethylphenyl-sulfonamido)methyl)-1H-benzo[d]imidazole-7-carboxylic acid (ACI-20) obtained in this way was coupled with 9-pyridin-4-Yl-3,9-diazaspiro[5.5]undecane dihydrochloride (AMN-01) under standard peptide coupling conditions. Yield: 20%

Provenance & Evidence